More than 850 million people in the world have a chronic kidney disease (CKD), a number that is still on the rise. CKD is a collective term for a wide variety of progressive, irreversible diseases, ultimately leading to kidney failure.
In many of these diseases, damage is done to the glomerulus, the filtration unit of the kidney. In response to this damage, inflammation is initiated, which often causes more damage, constituting a vicious cycle, ultimately leading to complete kidney failure.
Once insufficient kidney function is left, endogenous toxins start to accumulate in the body, slowly poisoning the person. In this stage the only options left are dialysis or kidney transplantation.