A single mRNA molecule, as the short-living copy of a single gene, can produce up to a few thousand therapeutic protein molecules on-site, making it very powerful and yet precise. The predictable behaviour and tunability allows for truly personalized medicine. And the relatively short lifetime of mRNA makes it much safer and more controllable than DNA, although this also poses a challenge.
Therefore, our mRNAs are modified in unique ways to optimize their stability and lifetime, and thereby maximize the therapeutic potential of each correctly delivered mRNA molecule.
We focus on target such as cytokines, transcription factors, bioactive peptides. These mostly have shorter mRNAs with associated benefits including possibilities for co-formulation, chemical production, and easier delivery.